concept

CELL SURVIVAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELL SURVIVAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

0Hypotheses

0Analyses

9Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CELL SURVIVAL
Key Genes/Proteins	AKT, SIRT1, SIRT3, MDM2, CR1, BDNF
Related Diseases	APOPTOSIS, PROTEIN MISFOLDING, NECROPTOSIS, MITOPHAGY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CELL_SURVIVAL["CELL SURVIVAL"]
    CELL_SURVIVAL -->|"regulates"| MITOPHAGY["MITOPHAGY"]
    CELL_SURVIVAL -->|"regulates"| NEURON["NEURON"]
    CELL_SURVIVAL -->|"regulates"| NEURONS["NEURONS"]
    CELL_SURVIVAL -->|"activates"| T_CELL["T CELL"]
    CELL_SURVIVAL -->|"activates"| T_CELLS["T CELLS"]
    CELL_SURVIVAL -->|"activates"| ULK1["ULK1"]
    CELL_SURVIVAL -->|"activates"| MTOR["MTOR"]
    CELL_SURVIVAL -->|"activates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    CELL_SURVIVAL -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    CELL_SURVIVAL -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    CLOCK["CLOCK"] -->|"regulates"| CELL_SURVIVAL
    PTEN["PTEN"] -->|"inhibits"| CELL_SURVIVAL
    PI3K["PI3K"] -->|"activates"| CELL_SURVIVAL
    PI3K_AKT_mTOR["PI3K-AKT-mTOR"] -->|"activates"| CELL_SURVIVAL
    AMPK["AMPK"] -->|"regulates"| CELL_SURVIVAL
    MTOR -->|"regulates"| CELL_SURVIVAL
    Autophagy["Autophagy"] -->|"involved_in"| CELL_SURVIVAL
    ULK1 -->|"contributes to"| CELL_SURVIVAL

Outgoing (9)

Target	Relation	Type	Str
PROTEIN MISFOLDING	protects_against	phenotype	0.65
PROTEIN MISFOLDING	stabilizes	phenotype	0.60
RESVERATROL	associated_with	concept	0.50
Proteins	expressed_in	protein	0.50
Neuroprotection	activates	process	0.50
GENE EXPRESSION	regulates	concept	0.50
Proteins	activates	protein	0.50
CORTEX	associated_with	brain_region	0.50
LITHIUM	associated_with	drug	0.50

Incoming (138)

Source	Relation	Type	Str
STRESS GRANULE ASSEMBLY	protects_against	entity	0.85
AKT	causes	gene	0.70
AKT	inhibits	gene	0.70
AKT	activates	gene	0.70
APOPTOSIS	activates	phenotype	0.70
SIRT1	inhibits	gene	0.70
SIRT3	regulates	gene	0.70
MDM2	targets	gene	0.65
CR1	activates	gene	0.65
NECROPTOSIS	stabilizes	phenotype	0.65
FIBROBLASTS	regulates	cell_type	0.65
MITOPHAGY	stabilizes	phenotype	0.60
BDNF	stabilizes	gene	0.60
SIRT1	implicated_in	gene	0.60
HMGB1	implicated_in	gene	0.55
MTOR	implicated_in	gene	0.55
MDM2	implicated_in	gene	0.55
AMPK	implicated_in	gene	0.55
CR1	implicated_in	gene	0.55
MITOCHONDRIA	regulates	cell_type	0.50
mitophagy	regulates	pathway	0.50
NEURONS	regulates	concept	0.50
Synaptic Transmission	regulates	pathway	0.50
IDO1	inhibits	gene	0.50
Autophagy	associated_with	process	0.50
ULK1	associated_with	gene	0.50
AMPK	associated_with	protein	0.50
MITOCHONDRIA	associated_with	cell_type	0.50
UBIQUITIN	expressed_in	protein	0.50
PPARGC1A	regulates	gene	0.50
PPARG	regulates	gene	0.50
CLUSTERIN	regulates	protein	0.50
cancer	regulates	disease	0.50
Autophagy	activates	process	0.50
mTOR	activates	entity	0.50
Neuroinflammation	inhibits	process	0.50
AMYLOID	inhibits	gene	0.50
AMYLOID BETA	inhibits	concept	0.50
Neurodegeneration	activates	disease	0.50
oxidative stress	activates	phenotype	0.50
PROTEIN MISFOLDING	activates	concept	0.50
TUMOR	regulates	disease	0.50
NF-κB	regulates	concept	0.50
TNF-α	regulates	concept	0.50
Neuron	regulates	cell_type	0.50
DOPAMINE	regulates	concept	0.50
AMPK	regulates	protein	0.50
LRP1	regulates	gene	0.50
ERBB2	associated_with	concept	0.50
EGFR	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CELL SURVIVAL

Understanding Entity Pages

Wiki Pages (20)

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